First and foremost, before you even think about international travel and purchasing tickets for flights or a bus ride to another country, you must have an international travel checklist.
Vaccinations are a requirement for airports all around the world today. Although some diseases may be more common in one area of the world, you can get any disease anywhere.
You need to make sure you have booked sufficient vacation time, and people know you are aware. This could be for work or help you manage your home while away.